Soutenance de thèse Davide Alocci
M. Davide Alocci soutiendra en anglais, en vue de l'obtention du grade de docteur ès sciences, mention bioinformatique, sa thèse intitulée:
An Interactive and Integrative View of Glycobiology
Date: Vendredi 28 septembre 2018 à 14h30
Lieu: CMU - 1, rue Michel Servet - Auditoire C150
Sous la direction de:
- Dr. Frédérique Lisacek
Glycosylation is one of the most abundant post-translational modifications (PTM) and the primary cause of microheterogeneity in proteins (glycoforms). It consists of the addition of a sugar moiety on the surface of a protein, and it has been suggested that over 50% of mammalian cellular proteins are typically glycosylated.
Despite its importance, glycobiology is still lacking concrete bioinformatics support which, in the last two decades, has boosted other major ’omics’ like proteomics, tran- scriptomics and genomics. Additionally, the inherent complexity of carbohydrates and the use of many orthogonal experimental techniques to elucidate a structure have slowed down the annotation of novel glycans leaving glycobiology fragmented internally.
This thesis aims at the creation of a collection of tools to reconstitute the puzzle of biological evidence produced by different glycomics experiments and, at the same time, fill the gap with other ’omics’.